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This study was designed to systematically evaluate the therapeutic potential of GHK-Cu in a dextran sulfate sodium (DSS)-induced murine model of UC, with particular emphasis on elucidating its regulatory effects on the NAD-dependent deacetylase sirtuin-1 (SIRT1)/signal transducer and activator of transcription 3 (STAT3) signaling pathway

Electrolyte monitoring is not routinely required for all GLP-1 users, but becomes essential when patients experience persistent gastrointestinal symptoms or have additional risk factors such as chronic kidney disease, heart failure, age over 65, or concurrent diuretic use